NEUROLOGY 2009;72:135-142
1403 women aged 71-89, a subset of WHI trial, were scanned on average four years apart. Frontal lobe volume was less at followup in women in estrogen or estrogen plus progesterone arms. Temporal lobe and total brain volume were not affected as markedly. The adverse effects are most evident in women experiencing cognitive deficits before initiating hormone therapy.
The cognitive measure used was the modified MMSE 3M
- Teng EL, Chui H. The Modified Mini-Mental State (3MS) Exam. J Clin Psychiatry 1987;48:314–318.
No comments:
Post a Comment