Ventral tegmental lesions causing pseudofrontal syndrome

Goldberg et al. Cortex 1989  Reticulofrontal disconnection
update see Miller Nat Rev Neurosci 2000

DA depletion in midbrain caused frontal disconnection.
"Kevin" had retrograde without anterograde amnesia

Analogy- (partial) to schizophhrenia that also affects mesolimbic (temporal) and mesocortical (frontal) projections.  EG argues schizophrenia represents a top down organizing defect ie. a type of auditory agnosia.  Behav Brain Sci 1991.