Meador KJ, Loring DW, Hulihan JF et al. Neurology 2003; 1483-1488.
TPM or VPA was added to CBZ in patients with partial epilepsy. After a 4 week baseline, subjects were titrated to 400 mg/d of TPM, 2250 of VPA or placebo and then maintained while undergoing vigorous test-retest neuropscyh. 62 patients were studied. TPM did slightly worse especially on COWAS (Controlled Oral Word Association Test) and Symbol Digit Modalities Test.
Martin R, Kuzniecky R, Ho S. COgnitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology 1999; 52: 321-327.
Among young healthy adults treated with TPM, GPN, LTG for 2 and 4 weeks only the TPM group showed neurocognitive effects especially on measures of attention and word fluency, whereas the other 2 groups had no changes.
Monday, February 4, 2008
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